Support your liver, kidneys and cholesterol. Split dose, preferably with food. Up to 2 doses daily can be taken safely, if needed. You may also wish to add TUDCA 500mg-1000mg daily alongside this supplement.
Each bottle contains 30 doses.
Benefits of Milk Thistle
Milk Thistle (also known as wild artichoke) is a thistle plant part of the daisy family, with a prickly stem and purple flowers. Milk Thistle has been used for thousands of years in the East and West respectively for liver disorders and protection. As Milk Thistle Extract, the active ingredient is mostly Silymarin (about 65-80%) and some fatty acids.
The actual bioavailability of pure Silymarin is around 0.95%, and for this reason it needs to be prepared as an ethanol extract or other method, which improves its water solubility, and thus has a higher bio-availability.
The main benefits of Milk Thistle are
- enhances liver protein synthesis
- encourages liver repair, probably due to the enhanced protein synthesis and its effect on RNA
- reduces inflammation and by proxy does a host of good things such as reducing tumor promoters, slowing calcium metabolism
In 72 patients with non-alcoholic hepatic steatosis (non-alcoholic fatty liver disease, NAFLD) on a controlled diet led to significantly reduced levels of alanine aminotransferase (ALT) and aspartame aminotransferase (AST) (AST/ALT < 1). Another parameter evaluated was γ-glutamyl transpeptidase (γ-GT). In NAFLD patients, γ-GT is high because of obesity, hyperinsulinemia, inflammation, and changes in the membrane permeability of the hepatocytes. The level of γ-GT decreased due to the silymarin-mediated inhibition of toxins entering the cells. Additionally, silymarin permits the stabilization of hepatocyte membranes. It also reduced the level of TNF-α, which reduces inflammation. A favorable change in the hepatorenal clearance index was also observed, which suggests a reduction in the accumulation of lipids in the liver. All of these results were visible after 6 months of treatment
It has two methods of action - hepatoprotective and regenerative. It's protective by reducting damage to cell membranes and impedes the entrance of toxins into the interior of liver cells. And regenerative as silymarin metabolically stimulates hepatic cells and activates the RNA iosynthesis of ribosomes to stimulate protein formation. Silymarin enhances hepatic glutathione generation by elevating cysteine availability and inducing cysteine synthesis while inhibiting its catabolism to taurine.
Hormonal data seems to indicate a positive effect, despite its impact to the androgen receptor. In 2012, 45 untrained men (average age 22) were given 140mg of silymarin per day (as an ethanol extract taken as a capsule). Compared with placebo, they gained about the same weight during this time (1.5kg), and lost 2.8% more body fat. The study also looked at groups doing endurance training and also saw similar changes to body fat loss when compared to placebo. In rats, Lutenizing Hormone is significantly increased (4.48ng to 6.40ng), as was testosterone (1.33ng to 1.74ng), when treated with 150mg/kg.
Ingredients & Function:
Artichoke Leaf (300mg per dose), Garlic Extract (500mg per dose), Plant Sterols (900mg per dose)
- Lowers LDL Cholesterol (or 'bad' cholesterol)
- Increases HDL Cholesterol (or 'good' cholesterol)
- Reduces Total Cholesterol
Milk Thistle, 210mg per dose
- Improves liver & kidney health